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Faculty Research Summary

Neurobiology

Cellular mechanisms underlying activity dependent competition and synaptic remodeling in the developing visual system Susan M Culican, M.D., Ph.D.
Assembly and function of neural circuits in the retina Daniel Kerschensteiner, PhD.
Neurobiology of the healthy and diseased vertabrate retina Peter D. Lukasiewicz, Ph.D.
Development of the visual brain and eye alignment Visual cortex development, ocular alignment, strabismus R. Lawrence Tychsen, M.D.

Immunology

How the innate immune system influences retinal or choroidal neovascularization Rajendra Apte, M.D., Ph.D.
Cellular and molecular regulation of the ocular immune response Immunological basis of age-related macular degeneration (AMD) Thomas A. Ferguson, Ph.D.

Molecular Biology

Crystallins and lens cell biology Usha P. Andley, Ph.D.
Apoptosis of retinal ganglion cells in rodent models of glaucoma Edward Barnett, M.D., Ph.D.
Role of anti-apoptotic proteins in lens cell biology Advanced microscopic techniques to eludicate the cellular basis of accommodation and presbyopia Steven Bassnett, Ph.D.
Identify mechanisms responsible for age-related cataracts, open angle glaucoma and corneal decompensation David C. Beebe, Ph.D.
Molecular basis of retinal specific gene expression and hereditary retinal degenerations
Treatment of ocular tumors
Shiming Chen, Ph.D.
Mechanisms of nuclear migration and anchorage in a single cell assays as well as their relevance to retinogenesis CNS development and skeletal muscle biology Didier Hodzic, Ph.D.
TGFb1-related corneal dystrophy, corneal ephithelial stem cells, corneal wound healing Andrew J.W. Huang, M.D., M.P.H.
Genetic eye disease
Cararact and glaucoma
Eye movement disorders
Alan Shiels, Ph.D.

Pharmacology/Physiology

Lens cell biology Steven Bassnett, Ph.D.
Aqueous humor dynamics Bernard Becker, M.D.
Mechanisma that determine the functioanl properties of mammalian rod and cone photoreceptors Vladimir Kefalov, Ph.D.
Synaptic basis of Retinal Information Processing
Roles of receptors for inhibitory and excitatory amino acids in the retina
Peter D. Lukasiewicz, Ph.D.
Development of biomaterials for ophthalmic applications Nathan Ravi, M.D., Ph.D.

Clinical Studies and Outcomes Research

Clinical trials investigating potential theraputic agents for retinal disease Rajendra Apte, M.D., Ph.D.
Lens cell biology Steven Bassnett, Ph.D.
Primary Investigator for the Ocular Hypertension Treatment Study Edward Barnett, M.D., Ph.D.
Multicenter randomized clinical trials to determine if medical treatment of ocular hypertension prevents or delays glaucomatous optic nerve damage
Quality of life assessments
Multicenter epidemiological study of keratoconus
Mae Gordon, Ph.D.
Immunocytology of corneal allograft rejection Anthony J. Lubniewski, M.D.
Visual Processing in Autism John Pruett, M.D., Ph.D.
Autofluorescence in posterior uveitis - a clinical trial looking into the role of a non-invasive imaging technique in monitoring patients with posterior uveitis. Micro RNA in intraocular lymphoma- a study of the micro-RNA profiles of samples taken from the eyes of patients with intraocular lymphoma. Outcomes following intraocular surgery in patients with uveitis - a retrospective review of the surgical outcomes of patients with uveitis.
MUST- Multicenter Uveitis Steroid Treatment Trial- an international clinical trial comparing intraocular steroid implant to systemic immunosuppression to treat uveitis.
P. Kumar Rao, MD
Neuroimaging features of papilledema
Visual and Neuroimaging findings in Neuromyelitis (NMO) patients Survey of Practice Pattern Variation in the management of Giant Cell Arteritis
Gregory P. Van Stavern, M.D.
Cataract Surgery Outcomes Analysis at VA
Research focusing on optimizing patient clinic flow and surgical OR throughput via the use of radio-frequency identification (RFID). This project will have direct impact on the delivery of both medical and surginal ophthalmic care at the John Cochran Medical Center.
David E. Vollman, M.D., M.B.A.
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The Vision Research Community at Washington University in St. Louis
Washington University School of Medicine
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