wustl.edu

Support for our endeavors
comes primarily from the
National Institutes of Health

Biography

Daniel Kerschensteiner, MD

kerschensteinerd@wustl.edu

Associate Professor, Ophthalmology and Visual Sciences
Associate Professor, Neuroscience
Associate Professor, Biomedical Engineering

We would like to understand the principles that guide the assembly of neural circuits and to decipher the way they process information. Our efforts concentrate on the mammalian retina. We use transgenic and ballistic gene delivery to fluorescently label specific neurons and connections in this circuit, and follow their development using confocal and two-photon imaging. In addition, we use light - the natural input to this circuit - to elicit signals with high precision and track the processing of visual information among successive neurons of the circuitry using patch-clamp and multi-electrode array recordings. By combining these approaches, we hope to identify features of the circuit architecture that perform particular computations and characterize how they arise during development. We will then probe underlying mechanisms of circuit assembly and function through genetically targeted manipulations of specific cells in the retina.

Education

  • MD, Georg-August University Göttingen, Germany, 2003

Training

  • Residency in Neurology Georg-August University Göttingen, Germany, 2002-2004
  • Fellow, Neuroscience, University College London, UK, 2004-2005
  • Fellow, Biological Structure, University of Washington, Seattle, WA, 2005-2009
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The Vision Research Community at Washington University in St. Louis
Washington University School of Medicine
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