wustl.edu

Support for our endeavors
comes primarily from the
National Institutes of Health

Biography

Vladimir Kefalov, PhD

Kefalov@vision.wustl.edu

Professor, Ophthalmology and Visual Sciences

 

 

Research Interests

  • Retina
  • Photoreceptor Neurobiology and Retinal Degeneration
  • Mechanisms of cone dark adaptation
  • Mechanisms of cone light adaptation
  • Pharmacological treatments of retinal degeneration

Education

  • MSc, in Physics, Department of Physics, Sofia University, Sofia, Bulgaria, 1993
  • PhD, in Cellular Biophysics, Department of Physiology, Boston University School of Medicine, Boston, Massachusetts, 1993-1999
    Advisor: Carter Cornwall, Ph.D., Research Topic: Physiology of the early events in visual pigment regeneration.
  • Postdoctoral Fellow, Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, 1999-2005
    Advisor: King-Wai Yau, Ph.D., Research Topic: Origins of the functional differences between retinal rod and cone photoreceptors.

Selected Publications

  • Xue Y., Shen S.Q., Corbo J.C., Kefalov V.J. (2015) Circadian and light-driven regulation of rod dark adaptation. Sci Rep 5 doi:10.1038/srep17616 http://f1000.com/images/badges/badgeforauthors.gif
  • Xue, Y, Shen, S.Q., Jui, J, Rupp, A.C., Byrne, L.C., Hattar, S, Flannery, J.G, Corbo, J.C., Kefalov, V.J. (2015) CRALBP supports the mammalian retina visual cycle and cone vision. J Clin Invest 125:727-738. http://f1000.com/images/badges/badgeforauthors.gif
  • Palczewska, G., Vinberg, F., Stremplewski, P., Bircher, M.P., Salom?, D., Komar, K., Zhang, J., Cascella, M.#, Wojtkowski, M.#, Kefalov, V.J.#, Palczewski, K.# (2014) Human infrared vision is triggered by two-photon chromophore isomerization. Proc Natl Acad Sci USA 111:E5445-54.
  • Wang, J.S., Nymark, S., Frederiksen, R., Estevez, M.E., Shen, S.Q., Corbo, J.C., Cornwall, M.C., Kefalov, V.J. (2014) Chromophore supply rate-limits mammalian photoreceptor dark adaptation. J Neurosci 34:11212-11221. http://f1000.com/images/badges/badgeforauthors.gif
  • Montana, C.L., Kolesnikov, A.V., Shen, S.Q., Myers, C.A., Kefalov, V.J., Corbo, J.C. (2013) Reprogramming of adult rod photoreceptors prevents retinal degeneration. Proc Natl Acad Sci USA 110, 1732-1737.  http://f1000.com/images/badges/badgeforauthors.gif
  • Sakurai, K., Chen, J., Kefalov, V.J.,  (2011). Role of guanylyl cyclase modulation in mouse cone phototransduction. J Neurosci 31, 7991-8000. http://f1000.com/images/badges/badgeforauthors.gif
  • Kolesnikov, A.V., Tang, P.H., Parker, R.O., Crouch, R.K., Kefalov, V.J., (2011). The mammalian cone visual cycle promotes M/L-cone pigment regeneration independently of the interphotoreceptor retinoid-binding protein. J Neurosci 31, 7900-7909.
  • Wang, J. and Kefalov, V.J. (2009). An alternative pathway mediates the mouse and human cone visual cycle. Current Biology 19:1665-1669. http://f1000.com/images/badges/badgeforauthors.gif
  • Wang, J., Estevez, M.E., Cornwell, M.C., and Kefalov, V.J. (2009). Intra-retinal visual cycle required for rapid and complete cone dark adaptation. Nature Neuroscience 12:295-302. (Journal Cover)
  • Kefalov, V.J., Estevez, M. E., Kono, M., Goletz, P. W., Crouch, R. K., Cornwall, M. C., and Yau, K.-W. (2005). Breaking the covalent bond - a pigment property that contributes to desensitization in cones. Neuron 46, 879-890. http://f1000.com/images/badges/badgeforauthors.gif
  • Kefalov*, V.J., Fu*, Y., Marsh-Armstrong, N., and Yau, K.-W. (2003). Role of visual pigment properties in rod and cone phototransduction. Nature. 425, 526-531. http://f1000.com/images/badges/badgeforauthors.gif
  • Kefalov, V.J., Crouch, R.K., and Cornwall, M.C. (2001). Role of noncovalent binding of 11-cis-retinal to opsin in dark adaptation of rod and cone photoreceptors. Neuron 29, 749-55. 
  •        (* equal contribution; # co-corresponding author)   


    © Copyright 2017    |    Contact Us    |    Directions    |    Login

    The Vision Research Community at Washington University in St. Louis
    Washington University School of Medicine
    660 S.Euclid Ave., St. Louis, Missouri 63110
    Campus Box 8096, McMillian Building, St. Louis, Missouri 63110