Support for our endeavors
comes primarily from the
National Institutes of Health


1. CrxRdy Cat: A Large Animal Model for CRX-Associated Leber Congenital Amaurosis. Occelli LM, Tran NM, Narfström K, Chen S, Petersen-Jones SM. Investigative Ophthalmology & Visual Science. 2016; 57(8):3780-92.

2. Nrl-Cre transgenic mouse mediates loxP recombination in developing rod photoreceptors. Brightman DS, Razafsky D, Potter C, Hodzic D, Chen S. Genesis 2016; 54(3):129-35.

3. Graded gene expression changes determine phenotype severity in mouse models of CRX-associated retinopathies. Ruzycki PA, Tran NM, Kefalov VJ, Kolesnikov AV, Chen S. Genome Biology. 2015; 16:171.

4. The transcription factor GTF2IRD1 regulates the topology and function of photoreceptors by modulating photoreceptor gene expression across the retina. Masuda T, Zhang X, Berlinicke C, Wan J, Yerrabelli A, Conner EA, Kjellstrom S, Bush R, Thorgeirsson SS, Swaroop A, Chen S, Zack DJ. Journal of Neuroscience 2014; 34(46):15356-68.

5. Mechanisms of blindness: animal models provide insight into distinct CRX-associated retinopathies. Tran NM, Chen S. Developmental Dynamics. 2014; 243(10):1153-66.

6Mechanistically distinct mouse models for CRX-associated retinopathy. Tran NM, Zhang A, Zhang X, Huecker JB, Hennig AK, Chen S. PLoS Genetics. 2014; 10(2):e1004111.

7. Transcription coactivators p300 and CBP are necessary for photoreceptor-specific chromatin organization and gene expression.  Hennig AK, Peng GH, Chen S.  PLoS One. 2013; 8(7):e69721.

8. Active opsin loci adopt intrachromosomal loops that depend on the photoreceptor transcription factor network. Peng GH, Chen S. Proceedings of the National Academy of Sciences of the United States of America. 2011; 108(43):17821-6.

9. Pias3-dependent SUMOylation controls mammalian cone photoreceptor differentiation. Onishi A, Peng GH, Chen S, Blackshaw S. Nature Neuroscience. 2010; 13(9):1059-65.

10. The orphan nuclear hormone receptor ERRbeta controls rod photoreceptor survival. Onishi A, Peng GH, Poth EM, Lee DA, Chen J, Alexis U, de Melo J, Chen S, Blackshaw S. Proceedings of the National Academy of Sciences of the United States of America. 2010; 107(25):11579-84.

11. Pias3-dependent SUMOylation directs rod photoreceptor development. Onishi A, Peng GH, Hsu C, Alexis U, Chen S, Blackshaw S. Neuron. 2009; 61(2):234-46.

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