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comes primarily from the
National Institutes of Health

Publications

Fundamental Research (*Corresponding Author)

  1. Nakamura R, Sene A, Santeford A, Gdoura A, Kubota S, Zapata N, Apte RS*. IL10-driven STAT3 signalling in senescent macrophages promotes pathological eye angiogenesis. Nat Commun. 2015; 6:7847. [PMID:26260587]

  2. Zhou Z, Doggett TA, Sene A, Apte RS, Ferguson TA. Autophagy supports survival and phototransduction protein levels in rod photoreceptors. Cell Death Differ. 2015; 22(3):488-98. [PMID:25571975]

  3. Sene A, Chin-Yee D, Apte RS*. Seeing through VEGF: innate and adaptive immunity in pathological angiogenesis in the eye. Trends Mol Med. 2015;21(1):43-51. Review. [PMID:25457617]

  4. Oladipupo SS, Smith C, Santeford A, Park C, Sene A, Wiley LA, Osei-Owusu P, Hsu J, Zapata N, Liu F, Nakamura R, Lavine KJ, Blumer KJ, Choi K, Apte RS, Ornitz DM. Endothelial cell FGF signaling is required for injury response but not for vascular homeostasis. Proc Natl Acad Sci U S A. 2014;111(37):13379-84. [PMID: 25139991]

  5. Silberman DM, Ross K, Sande PH, Kubota S, Ramaswamy S, Apte RS, Mostoslavsky R. SIRT6 is required for normal retinal function. PLoS One. 2014; 9(6) [PMID:24896097]

  6. Stein LR, Wozniak DF, Dearborn JT, Kubota S, Apte RS, Izumi Y, Zorumski CF, Imai S. Expression of Nampt in hippocampal and cortical excitatory neurons is critical for cognitive function. J Neurosci. 2014; 34(17):5800-15. doi: [PMID:24760840]

  7. Sene A, Apte RS*. Eyeballing cholesterol efflux and macrophage function in disease pathogenesis. Trends Endocrinol Metab. 2014; 25(3):107-14. Review. [PMID: 24252662]

  8. Zhao H, Roychoudhury J, Doggett TA, Apte RS, Ferguson TA. Age-dependent changes in FasL (CD95L) modulate macrophage function in a model of age-related macular degeneration. Invest Ophthalmol Vis Sci. 2013;54(8):5321-31. [PMID:23821188]

  9. Sene A, Khan AA, Cox D, Nakamura RE, Santeford A, Kim BM, Sidhu R, Onken MD, Harbour JW, Hagbi-Levi S, Chowers I, Edwards PA, Baldan A, Parks JS, Ory DS, Apte RS*. Impaired cholesterol efflux in senescent macrophages promotes age-related macular degeneration. Cell Metab. 2013;17(4):549-61. [PMID:23562078]

  10. Cruz-Guilloty F, Saeed AM, Echegaray JJ, Duffort S, Ballmick A, Tan Y, Betancourt M, Viteri E, Ramkhellawan GC, Ewald E, Feuer W, Huang D, Wen R, Hong L,       Wang H, Laird JM, Sene A, Apte RS, Salomon RG, Hollyfield JG, Perez VL. Infiltration of proinflammatory m1 macrophages into the outer retina precedes damage in a mouse model of age-related macular degeneration. Int J Inflam. 2013; 2013:503725. [PMID: 23533946]

  11. Schimel AM, Abraham L, Cox D, Sene A, Kraus C, Dace DS, Ercal N, Apte RS*  N-acetylcysteine amide (NACA) prevents retinal degeneration by up-regulatingreduced glutathione production and reversing lipid peroxidation. Am J Pathol. 2011; 178(5):2032-43

  12. Apte RS. Regulation of angiogenesis by macrophages. Adv Exp Med Biol 2010; 664:15-9. [PMID:20237997]

  13. Khan AA, Dace DS, Ryazanov A, Kelly J, Apte RS. Resveratrol regulates pathologic angiogenesis by a eukaryotic elongation factor-2 kinase regulated pathway. AmJ Pathol 2010; 177(1):481-92. [PMID:20472894] [PMCID:PMC2893690]

  14. Roychoudhury J, Herndon JM, Yin J, Apte RS, Ferguson TA. Targeting immune privilege to prevent pathogenic neovascularization. Invest Ophthalmol Vis Sci 2010;51(7):3560-6. [PMID:20164456] [PMCID:PMC2904009]

  15. Brantley MA Jr, Edelstein SL, King JM, Plotzke MR, Apte RS, et al. Association of complement factor H and LOC387715 genotypes with response of exudative age-related macular degeneration to photodynamic therapy. Eye 2009; 23(3):626-31. [PMID:18292785]

  16. Dace D, Khan AA, Kelly J, Apte RS. Interleukin-10 promotes pathological angiogenesis by regulating macrophage response to hypoxia during development. PloSOne 2008; 3(10):3381. [PMID:18852882] [PMCID:PMC2557127]

  17. Khan AA, Apte RS. An assay for macrophage mediated regulation of endothelial cell proliferation. Immunobiology 2008; 213(9-10):695-9. [PMID:18926285][PMCID:PMC2572032]

  18. Ferguson TA, Apte RS. Angiogenesis in eye disease: Immunity gained or lost? Seminars in Immunopathology 2008; 30(2):111-9. [PMID:18297288]

  19. Dace D, Apte RS. The effect of senescence on macrophage polarization and angiogenesis. Rejuvenation Res 2008; 11(1):177-85. [PMID:18279031]

  20. Kelly J, Khan AA, Yin J, Ferguson TA, Apte RS. Senescence regulates macrophage polarization and angiogenic fate at sites of tissue injury. J Clin Invest 2007;117:3421-6. [PMID:17975672] [PMCID:PMC2045608]

Translational Research

  1. Kumar GN, Rao PK, Apte RS*Microstructural retinal findings by spectral-domain optical coherence tomography after vitrectomy repair of rhegmatogenous retinal detachments. Ophthalmic Surg Lasers Imaging Retina. 2015 (4):493-8. [PMID:25932731]
  2. Oshima Y, Apte RS, Nakao S, Yoshida S, Ishibashi T. Full thickness macular hole case after intravitreal aflibercept treatment. BMC Ophthalmol. 2015;15:30. [PMID:
    25881212]
  3. Earl JB, Lee CS, Yom V, Van Stavern GP, Abuattieh M, Chin-Yee D, Rao PK, Apte RS*. Visual cycle suppression via patching in central serous chorioretinopathy.

    Ophthalmology. 2014;121(12):2502-4. [PMID:25109933]

  4. Rao RC, Choudhry N, Apte RS*.  Subconjunctival bevacizumab for iris neovascularisation - Authors' reply. Lancet Diabetes Endocrinol. 2014;2(6):450-1. [PMID: 
    24880562]
  5. Rao RC, Choudhry N, Apte RS*. Regression of iris neovascularisation secondary to diabetic retinopathy with subconjunctival anti-VEGF therapy.  Lancet Diabetes Endocrinol. 2014; 2(2):182. [PMID:24622722]
  6. Nguyen-Khoa BA, Goehring EL, Werther W, Fung AE, Do DV, Apte RS, Jones JK. Hospitalized cardiovascular events in patients with diabetic macular edema. 

    BMC Ophthalmol. 2012;12:11. [PMID:22646811]

  7. Dewan V, Lambert D, Edler J, Kymes S, Apte RS*. Cost-effectiveness analysis of ranibizumab plus prompt or deferred laser or triamcinolone plus prompt laser for diabetic macular edema. Ophthalmology. 2012;119(8):1679-84. [PMID:22503301]
  8.  Kraus CL, Rao PK, Apte RS*. Effect of preoperative vitreous status on visual outcomes following vitrectomy for epiretinal membrane repair. Can J Ophthalmol. 2011;46(2):186-90. [PMID:21708089]
  9. Sheybani A, Brantley MA Jr., Apte RS. Pattern electroretinography in age-related macular degeneration. Arch Ophthalmol 2011; 129(5):580-4. [PMID:2155610]

Published Abstracts

  1. Pitha IF, Sporn MB, Apte RS. Inhibition of Choroidal Neovascularization by the Synthetic Oleanane Triterpenoid CDDO-Im. (E-Abstract #4879) Invest Ophthalmol Vis Sci 2011: Annual Meeting Abstract and Program Planner accessed at www.arvo.org. Association for Research in Vision and Ophthalmology.
  2. Kraus CL, Rao K, Apte RS. The Effect of Pre-Operative Vitreous Status on Visual Outcomes Following Epiretinal Membrane Surgery. (E-Abstract #3608) Invest Ophthalmol Vis Sci 2011: Annual Meeting Abstract and Program Planner accessed at www.arvo.org. Association for Research in Vision and Ophthalmology.
  3. Dewan V, Lambert D, Kymes S, Apte RS. A Cost-Effectiveness Analysis of the Randomized Trial Evaluating Ranibizumab Plus Prompt or Deferred Laser or Triamcinolone Plus Prompt Laser for Diabetic Macular Edema. (E-Abstract #559) Invest Ophthalmol Vis Sci 2011: Annual Meeting Abstract and Program Planner accessed at www.arvo.org. Association for Research in Vision and Ophthalmology.
  4. Sheybani A, Brantley MA, Apte RS. Choroidal Neovascularization Assessment by Pattern Electroretinography after Ranibizumab in Naïve Age-Related Macular Degeneration Patients (CAPTAIN). (E-Abstract #6417) Invest Ophthalmol Vis Sci 2010; 51 Annual Meeting Abstract and Program Planner accessed at www.arvo.org. Association for Research in Vision and Ophthalmology.
  5. Khan AA, Dace D, Ryazanov AG, Kelly J, Apte RS. Resveratrol Regulates Pathologic Angiogenesis by a Eukaryotic Elongation Factor-2 Kinase Pathway. (E-Abstract #6383) Invest Ophthalmol Vis Sci 2010; 51 Annual Meeting Abstract and Program Planner accessed at www.arvo.org. Association for Research in Vision and Ophthalmology.
  6. Khan AA, Dace D, Ryazanov AG, Kelly J, Apte RS. Resveratrol Regulates Pathologic Angiogenesis by a Eukaryotic Elongation Factor-2 Kinase Pathway. (E-Abstract #6383) Invest Ophthalmol Vis Sci 2010; 51 Annual Meeting Abstract and Program Planner accessed at www.arvo.org. Association for Research in Vision and Ophthalmology.
  7. . Chu FB, Vollman DE, Apte RS, Cohen BH, Siegfried CJ, Kymes SM. An economic evaluation of prophylactic NSAID use with cataract surgery to prevent cystoid macular edema (E-Abstract #4562) Invest Ophthalmol Vis Sci 2010; 51 Annual Meeting Abstract and Program Planner accessed at www.arvo.org. Association for Research in Vision and Ophthalmology.
  8. Abraham LS, Schimel AM, Apte RS, et al. Tert-Butyl Hydroperoxide Induced Oxidative Damage in ARPE-19 Cells and Protection by N-Acetylcysteine Amide, a Low Molecular Weight Thiol Antioxidant. Free Radical Biology and Medicine 2008; 45(supp 1):S78.
  9. . Schadlu R, Apte RS. Treatment of exudative age-related macular degeneration with PDT and intravitreal injection of triamcinolone acetate. (Abstract #313) Invest Ophthalmol Vis Sci 2005; 46(suppl S).
  10. Apte RS, Gonzalez RAB, Ferguson TA. Role of IL-10 in choroidal neovascularization. (Abstract #2228) Invest Ophthalmol Vis Sci 2004; 45(supp 1):U804.

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The Vision Research Community at Washington University in St. Louis
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